Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer

http://biorxiv.org/content/early/2016/06/02/056770

Jeff F HikenJames I McDonaldKeith F DeckerCesar SanchezJeremy HoogNathan D VanderKraatsKyle LJungMargaret AkinhanmiMatthew J EllisJohn R Edwards


Preprint journal club review posted to The Winnower: review

-Sandipto Sarkar and Everett Hall, University of Kansas Medical Center, Interdisciplinary Graduate Program in Biomedical Sciences

Regions of very low H3K27me3 partition the Drosophila genome into topological domains

http://biorxiv.org/content/early/2016/09/01/072900

Sherif El-SharnoubyBettina FischerJose Paolo MagbanuaBenjamin UmansRosalynFlowerSiew Woh ChooSteven RussellRob White


Preprint journal club review posted to The Winnower: review

-Xuanying Li and Zainab Afzal, University of Kansas Medical Center, Interdisciplinary Graduate Program in Biomedical Sciences

Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling

http://biorxiv.org/content/early/2016/08/21/070623

Giovanni LuchettiRia SircarJennifer H KongSigrid NachtergaeleAndreas SagnerEamon FX ByrneDouglas F CoveyChristian SieboldRajat Rohatgi


Preprint journal club review posted to The Winnower: review

-Wei Wang and Cassi Johnson, University of Kansas Medical Center, Interdisciplinary Graduate Program in Biomedical Sciences

 

Loss of doublecortin (DCX) domain containing protein causes structural defects in tubulin-based organelle of Toxoplamsa gondii and impairs host cell invasion

http://biorxiv.org/content/early/2016/08/12/069377

Eiji NagayasuYu-chen HwangJun LiuJohn MurrayKe Hu


Preprint journal club review posted to The Winnower: review

-Cassi Johnson and Sandipto Sarkar, University of Kansas Medical Center, Interdisciplinary Graduate Program in Biomedical Sciences

 

ALADIN is Required for the Production of Fertile Mouse Oocytes.

http://biorxiv.org/content/early/2016/03/11/043307


-Stephen J. Royle, University of Warwick

 

Exact length distribution of filamentous structures assembled from a finite pool of subunits

http://biorxiv.org/content/early/2016/03/02/042184


For years I have been writing reviews about size control and I always am stumped by what to say we should expect if there is no size control mechanism in place, i..e there is just a fixed set of subunits and they self-assemble but no additional system is measuring or modulating the size.   what is the null hypothesis?   the answer is not at all obvious and so what they have done in this mansucript seems very important to me, since now we can define in very precise terms what the null hypothesis should be.   If the authors are looking for good examples of cellular sub-structures whose sizes are power-law distributed, one example is IFT trains (see Ludington et al, 2013).

-Wallace Marshall, UCSF