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Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling

November 29, 2016November 29, 2016 PracheeLeave a comment

http://biorxiv.org/content/early/2016/08/21/070623

Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon FX Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi

Preprint journal club review posted to The Winnower: review

-Wei Wang and Cassi Johnson, University of Kansas Medical Center, Interdisciplinary Graduate Program in Biomedical Sciences

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Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer
Regions of very low H3K27me3 partition the Drosophila genome into topological domains
Hipk is required for JAK/STAT activity and promotes hemocyte-derived tumorigenesis
Chytrid fungi construct actin-rich pseudopods, implicating actin regulators WASP and SCAR in an ancient mode of cell motility
Zfp423 regulates Sonic hedgehog signaling via primary cilium function

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